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Immune checkpoint inhibitors can stimulate antitumor immunity but can also induce toxicities termed immune-related adverse events (irAEs). Colitis is a common and severe irAE that can lead to treatment discontinuation. Mechanistic understanding of gut irAEs has been hampered because robust colitis is not observed in laboratory mice treated with checkpoint inhibitors. We report here that this limitation can be overcome by using mice harboring the microbiota of wild-caught mice, which develop overt colitis following treatment with anti-CTLA-4 antibodies. Intestinal inflammation is driven by unrestrained activation of IFNγ-producing CD4⁺T cells and depletion of peripherally induced regulatory T cells through Fcγ receptor signaling. Accordingly, anti-CTLA-4 nanobodies that lack an Fc domain can promote antitumor responses without triggering colitis. This work suggests a strategy for mitigating gut irAEs while preserving antitumor stimulating effects of CTLA-4 blockade. 

We propose an over-the-air learning framework for collaborative decision making in wireless sensor networks. The low complexity framework leverages low-latency sensor transmission for a decision server to coordinate measurement sensors for hypothesis testing through over-the-air aggregation of sensor data over a multiple-access channel. We formulate several collaborative over-the-air hypothesis testing problems under different practical protocols for collaborative learning and decision making. We develop hypothesis tests for these network protocols and deployment scenarios including channel fading. We provide performance benchmark for both basic likelihood ratio test and generalized likelihood ratio test under different deployment conditions. Our results clearly demonstrate gain provided by increasing number of collaborative sensors. 

We propose an over-the-air learning framework for collaborative decision making in wireless sensor networks. The low complexity framework leverages low-latency sensor transmission for a decision server to coordinate measurement sensors for hypothesis testing through over-the-air aggregation of sensor data over a multiple-access channel. We formulate several collaborative over-the-air hypothesis testing problems under different practical protocols for collaborative learning and decision making. We develop hypothesis tests for these network protocols and deployment scenarios including channel fading. We provide performance benchmark for both basic likelihood ratio test and generalized likelihood ratio test under different deployment conditions. Our results clearly demonstrate gain provided by increasing number of collaborative sensors. 

Deformable beamsplitters have been shown as a means of creating a wide field of view, varifocal, optical see- through, augmented reality display. Current systems suffer from degraded optical quality at far focus and are tethered to large air compressors or pneumatic devices which prevent small, self-contained systems. We present an analysis on the shape of the curved beamsplitter as it deforms to different focal depths. Our design also demonstrates a step forward in reducing the form factor of the overall system.